1,2-Dihydrobudesonide (Mixture of diastereomers)

• CAT Number: R017957
• CAS Number: 137174-25-5
• Molecular Formula: C25H36O6
• Molecular Weight: 432.557
• Purity: ≥95%
• Synonyms: (11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregn-4-ene-3,20-dione
• Appearance: Off-White to Pale Yellow Solid
• Storage: -20°C
• IUPAC Name: (1S,2S,4S,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
• InChI: InChI=1S/C25H36O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h10,16-18,20-22,26,28H,4-9,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
• InChIKey: UEXJIOHTZFZGOQ-KWVAZRHASA-N
• SMILES: CCCC1OC2CC3C4CCC5=CC(=O)CCC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C

1,2-Dihydrobudesonide (Mixture of diastereomers) is a synthetic corticosteroid and a derivative of budesonide, featuring a reduced form at the 1,2-position of the steroid backbone. As a mixture of diastereomers, it contains different stereochemical configurations, which may influence its biological activity and pharmacokinetic properties. Like budesonide, it is used for its anti-inflammatory and immunosuppressive properties, making it relevant in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Researchers utilize 1,2-Dihydrobudesonide to explore its potential therapeutic effects, comparing its efficacy and stability to budesonide in pharmaceutical development and drug optimization.