For research use only. Not for therapeutic Use.
1,2-<wbr></wbr>Dipalmitoyl-<wbr></wbr><em>sn</em>-<wbr></wbr>glycero-<wbr></wbr>3-<wbr></wbr>PE (1,2-<wbr></wbr>DPPE) is a naturally-<wbr></wbr>occurring PE containing 16:0 fatty acids at the <em>sn</em>-<wbr></wbr>1 and <em>sn</em>-<wbr></wbr>2 positions. It belongs to a class of phospholipids that are the most abundant lipids in the inner leaflet of the plasma membrane. 1,2-<wbr></wbr>DPPE interacts with cholesterol to form a condensed lipid monolayer with tight hydrogen bonding of the 1,2-<wbr></wbr>DPPE interheadgroups, resulting in a more fluid membrane that may aid in transport and signaling across the bilayer.
| Catalog Number | R018583 |
| CAS Number | 923-61-5 |
| Synonyms | 1,2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine;1,2-DPPE |
| Molecular Formula | C37H74NO8P |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Storage | -20°C |
| IUPAC Name | [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate |
| InChI | InChI=1S/C37H74NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-36(39)43-33-35(34-45-47(41,42)44-32-31-38)46-37(40)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h35H,3-34,38H2,1-2H3,(H,41,42)/t35-/m1/s1 |
| InChIKey | SLKDGVPOSSLUAI-PGUFJCEWSA-N |
| SMILES | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCCCCCCCCC |
| Reference | <br>1. M. Bogdanov, W. Dowhan, “Lipid-assisted Protein Folding” Journal of Biological Chemistry, Vol. 274 pp. 36827-36830, 1999<br>2. J. Vance, “Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids” Journal of LipidResearch, Vol. 49 pp. 1377-1387, 2008<br>3. D. Lang et al., “Molecular Species Analysis of 1,2-Diglycerides on Phorbol Ester Stimulation of LA-N-1 Neuroblastoma Cells During Proliferation andDifferentiation” Journal of Neurochemistry, Vol. 65 pp. 810, 1995</br></br></br> |
