12-Hydroxy Irinotecan (Mixture of Diastereomers)

• CAT Number: R051722
• CAS Number: 185336-12-3
• Molecular Formula: C33H38N4O7
• Molecular Weight: 602.688
• Purity: ≥95%
• Synonyms: [1,4’-Bipiperidine]-1’-carboxylic Acid (4S)-4,11-diethyl-3,4,12,14-tetrahydro- 4,12-dihydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl Ester; (4S)-4,11-Diethyl-4,12-dihydroxy-9-[(4-piperidinopiperidino)carbonyloxy]-1H-pyrano[3’,4
• Storage: -20°C
• InChI: InChI=1S/C33H38N4O7/c1-3-21-22-16-20(44-32(41)36-14-10-19(11-15-36)35-12-6-5-7-13-35)8-9-25(22)34-28-26-17-24-23(18-43-31(40)33(24,42)4-2)29(38)37(26)30(39)27(21)28/h8-9,16-17,19,30,39,42H,3-7,10-15,18H2,1-2H3/t30?,33-/m0/s1
• InChIKey: XQUUJPQAMJFQHV-OQGPVULJSA-N
• SMILES: CCC1=C2C=C(C=CC2=NC3=C1C(N4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O)OC(=O)N6CCC(CC6)N7CCCCC7

12-Hydroxy Irinotecan (Mixture of Diastereomers) is a metabolite and derivative of irinotecan, a chemotherapeutic agent used primarily in the treatment of colorectal cancer. Irinotecan works by inhibiting topoisomerase I, an enzyme essential for DNA replication, leading to cell death in rapidly dividing cancer cells. The hydroxylation at the 12-position introduces stereocenters, resulting in a mixture of diastereomers, which can exhibit differing biological activities and pharmacokinetics. The study of 12-Hydroxy Irinotecan and its diastereomers is important for understanding the drug’s metabolism, efficacy, and potential side effects, and can contribute to optimizing cancer treatment regimens.