12R-LOX-IN-2

• CAT Number: I040721
• CAS Number: 3026677-37-9
• Molecular Formula: C19H13NO
• Molecular Weight: 271.31
• Purity: ≥95%
• Synonyms: 4-quinolin-2-ylnaphthalen-1-ol
• InChI: InChI=1S/C19H13NO/c21-19-12-10-15(14-6-2-3-7-16(14)19)18-11-9-13-5-1-4-8-17(13)20-18/h1-12,21H
• InChIKey: PLATVCRZPNTREE-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C4=CC=CC=C43)O

12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases[1].

Reference

[1]. Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.. .
 [Content Brief]