For research use only. Not for therapeutic Use.
Prostaglandin E<sub>1</sub> (PGE<sub>1</sub>) is produced by the metabolism of dihomo-<wbr></wbr>γ-<wbr></wbr>linolenic acid (DGLA) by the cyclooxygenase pathway. PGE<sub>1</sub> inhibits platelet aggregation (IC<sub>50</sub> = 40 nM) and increases vasodilation. 13,14-<wbr></wbr>dihydro-<wbr></wbr>16,16-<wbr></wbr>difluoro PGE<sub>1</sub> is an analog of PGE<sub>1</sub>. 13,14-<wbr></wbr>dihydro PGE<sub>1</sub> is a biologically active metabolite of PGE<sub>1</sub>, inhibiting platelet aggregation with comparable potency to the parent compound. The addition of two electron-<wbr></wbr>withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation <em>in vivo</em>.
| Catalog Number | R067402 |
| CAS Number | 475992-30-4 |
| Synonyms | 15-hydroxy Lubiprostone |
| Molecular Formula | C20H34F2O5 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C20H34F2O5/c1-2-3-12-20(21,22)18(25)11-10-15-14(16(23)13-17(15)24)8-6-4-5-7-9-19(26)27/h14-15,17-18,24-25H,2-13H2,1H3,(H,26,27)/t14-,15-,17-,18-/m1/s1 |
| InChIKey | PNVYHTHOCKTJCO-JOCBIADPSA-N |
| SMILES | O=C1[C@H](CCCCCCC(O)=O)[C@@H](CC[C@@H](O)C(F)(F)CCCC)[C@H](O)C1 |
| Reference | 1.Kobzar, G.,Mardla, V.,Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proceedings of the Estonian Academy of Sciences.Chemistry 40, 179-180 (1991). |
