1,4,8,11-Tetraazacyclotetradecane

• CAT Number: R039608
• CAS Number: 295-37-4
• Molecular Formula: C10H24N4
• Molecular Weight: 200.33
• Purity: ≥95%
• Synonyms: Cyclam; JM 1498; NSC 180811
• Storage: Store at +4C
• IUPAC Name: 1,4,8,11-tetrazacyclotetradecane
• InChI: InChI=1S/C10H24N4/c1-3-11-7-9-13-5-2-6-14-10-8-12-4-1/h11-14H,1-10H2
• InChIKey: MDAXKAUIABOHTD-UHFFFAOYSA-N
• SMILES: C1CNCCNCCCNCCNC1

1,4,8,11-Tetraazacyclotetradecane (CAS 295-37-4) is an azamacrocycle that forms more stable metal complexes as compared to open chain ligands. It can be used as a ligand in the synthesis of cyanide-bridged FeIII-CuII complexes and Zn(II) complexes with flufenamic acid (flu).

Reference

1.Füzerová, Silvia, et al. "Cyclam (1, 4, 8, 11-tetraazacyclotetradecane) with one methylphosphonate pendant arm: a new ligand for selective copper (II) binding." Dalton transactions 17 (2005): 2908-2915.
2.Shi, Jingwen, et al. "A serials of sandwich-like trinuclear and one-dimensional chain cyanide-bridged iron (III)-copper (II) complexes: Syntheses, crystal structures and magnetic properties." Journal of Solid State Chemistry 260 (2018): 59-66.
3.Smolková, R., et al. "Novel Zn (II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies." Journal of Inorganic Biochemistry 177 (2017): 143-158.