1,5-Isoquinolinediol

• CAT Number: R050718
• CAS Number: 5154-02-9
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Purity: ≥95%
• Synonyms: 5-Hydroxy-isoquinolinone; 1,5-Dihydroxyisoquinoline; NSC 65585
• Target: Epigenetics
• Storage: 4°C
• IUPAC Name: 5-hydroxy-2H-isoquinolin-1-one
• InChI: InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
• InChIKey: LFUJIPVWTMGYDG-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=CNC2=O)C(=C1)O

The poly(ADP-<wbr></wbr>ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-<wbr></wbr>Isoquinolinediol is an inhibitor of poly(ADP-<wbr></wbr>ribose) synthetase (PARP1; IC50 = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-<wbr></wbr>induced cell death. This compound can be used with cells in culture and in animals.