For research use only. Not for therapeutic Use.
The poly(ADP-<wbr></wbr>ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-<wbr></wbr>Isoquinolinediol is an inhibitor of poly(ADP-<wbr></wbr>ribose) synthetase (PARP1; IC<sub>50</sub> = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-<wbr></wbr>induced cell death. This compound can be used with cells in culture and in animals.
| Catalog Number | R050718 |
| CAS Number | 5154-02-9 |
| Synonyms | 5-Hydroxy-isoquinolinone; 1,5-Dihydroxyisoquinoline; NSC 65585; |
| Molecular Formula | C9H7NO2 |
| Purity | ≥95% |
| Target | Epigenetics |
| Storage | 4°C |
| IUPAC Name | 5-hydroxy-2H-isoquinolin-1-one |
| InChI | InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12) |
| InChIKey | LFUJIPVWTMGYDG-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=CNC2=O)C(=C1)O |
