15-Keto Travoprost

• CAT Number: R053380
• CAS Number: 404830-45-1
• Molecular Formula: C26H33F3O6
• Molecular Weight: 498.5
• Purity: ≥95%
• Synonyms: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester; 15-keto Fluprostenol Isopropyl Ester
• Target: Drug Metabolite
• Storage: -20°C
• InChIKey: KSDDYCRRTVADFZ-OHDKTVHDSA-N

Travoprost is an F-<wbr></wbr>series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-<wbr></wbr>15 hydroxyl group without isopropyl ester hydrolysis produces 15-<wbr></wbr>keto fluprostenol isopropyl ester (15-<wbr></wbr>keto travoprost). 15-<wbr></wbr>keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-<wbr></wbr>keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-<wbr></wbr>series prostaglandin analogs with a 15-<wbr></wbr>keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response. The efficacy of 15-<wbr></wbr>keto travoprost as an ocular hypotensive has not been established.