15-PGDH-IN-1

• CAT Number: I042580
• CAS Number: 2241676-74-2
• Molecular Formula: C24H22N4O2
• Molecular Weight: 398.46
• Purity: ≥95%
• Synonyms: 2-methyl-6-[7-(piperidine-1-carbonyl)quinoxalin-2-yl]isoquinolin-1-one
• InChI: InChI=1S/C24H22N4O2/c1-27-12-9-16-13-17(5-7-19(16)24(27)30)22-15-25-20-8-6-18(14-21(20)26-22)23(29)28-10-3-2-4-11-28/h5-9,12-15H,2-4,10-11H2,1H3
• InChIKey: URHPFANOQLIROT-UHFFFAOYSA-N
• SMILES: CN1C=CC2=C(C1=O)C=CC(=C2)C3=CN=C4C=CC(=CC4=N3)C(=O)N5CCCCC5

15-PGDH-IN-1 (Cat No.: I042580) is a selective small-molecule inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme responsible for degrading prostaglandins such as PGE2. By blocking 15-PGDH activity, this compound enhances prostaglandin signaling, promoting tissue regeneration, stem cell function, and anti-inflammatory responses. 15-PGDH-IN-1 has shown therapeutic potential in preclinical models of colitis, bone marrow recovery, and other regenerative applications. It is a valuable research tool for studying prostaglandin metabolism and evaluating the role of 15-PGDH in inflammation, tissue repair, and disease modulation.

Reference

[1]. Bin Hu, et al. Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration. J Med Chem. 2022 Nov 2.
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