For research use only. Not for therapeutic Use.
15(R)-Prostaglandin I<sub>2</sub> (15(R)-PGI<sub>2</sub>) is an isomer of the natural 15(S) prostanoid, PGI<sub>2</sub> (Item No. <span class=/itemid/>18220</span>). PGI<sub>2</sub> is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC<sub>50</sub> value of 5 nM. While the physiological properties of 15(R)-PGI<sub>2</sub> are not well known, 15(R) isomers of PGs typically have reduced receptor agonist activity compared to their 15(S) forms.
| Catalog Number | R066992 |
| Synonyms | 15(R)-PGI2 |
| Molecular Formula | C20H31O5 • Na |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22;/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,15-8-;/t14-,16-,17-,18-,19+;/m1./s1 |
| InChIKey | LMHIPJMTZHDKEW-MYQOGOCISA-M |
| SMILES | CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(O2)=C/CCCC([O-])=O.[Na+] |
| Reference | 1.Moncada, S.,Gryglewski, R.,Bunting, S., et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263, 663-665 (1976). |
