16α-Methyl-9,11-dehydro Prednisolone

• CAT Number: R050590
• CAS Number: 13209-41-1
• Molecular Formula: C22H28O4
• Molecular Weight: 356.462
• Purity: ≥95%
• Synonyms: (16α)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; 17α,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione; Dexamethasone Impurity E (EP)
• Target: Vitamin D Related/Nuclear Receptor
• Storage: -20°C
• IUPAC Name: (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1
• InChIKey: ZYTXTXAMMDTYDQ-DGEXFFLYSA-N
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1(C(=O)CO)O)C)C

16α-Methyl-9,11-dehydro Prednisolone is a synthetic glucocorticoid derivative, structurally modified from prednisolone. The addition of a methyl group at the 16α position and the introduction of a double bond between the 9 and 11 positions enhance its anti-inflammatory and immunosuppressive activities. Like other glucocorticoids, it works by modulating the body’s immune response and reducing inflammation, making it useful in treating conditions such as autoimmune diseases, allergies, and inflammatory disorders. The structural modifications also improve its potency and bioavailability, making 16α-Methyl-9,11-dehydro Prednisolone a valuable compound in therapeutic applications where enhanced glucocorticoid activity is required.