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38315-44-5-16-phenyl tetranor Prostaglandin E2 16-phenyl tetranor Prostaglandin E2

16-phenyl tetranor Prostaglandin E2

For research use only. Not for therapeutic Use.

  • CAT Number: R064907
  • CAS Number: 38315-44-5
  • Molecular Formula: C22H28O5
  • Molecular Weight: 372.5
  • Purity: ≥95%
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Related Small Molecules: 5-Morpholino-2-phenyl-1,3-oxazol-4-yl cyanide     Fmoc-N-methyl-D-valine     H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2    

16-<wbr></wbr>phenyl tetranor PGE<sub>2</sub> is a metabolically stable synthetic analog of PGE<sub>2</sub>. 16-<wbr></wbr>phenyl tetranor PGE<sub>2</sub> is five times more potent than PGE<sub>2</sub> in causing hypotension in dogs (0.1 µg/kg dose). It is comparable to PGE<sub>2</sub> in inhibiting histamine-<wbr></wbr>induced bronchoconstriction in conscious guinea pigs.


Catalog Number R064907
CAS Number 38315-44-5
Synonyms

16-phenyl tetranor PGE2

Molecular Formula C22H28O5
Purity ≥95%
Storage -20°C
InChI InChI=1S/C22H28O5/c23-17(14-16-8-4-3-5-9-16)12-13-19-18(20(24)15-21(19)25)10-6-1-2-7-11-22(26)27/h1,3-6,8-9,12-13,17-19,21,23,25H,2,7,10-11,14-15H2,(H,26,27)/b6-1-,13-12+/t17-,18-,19-,21-/m1/s1
InChIKey DXWJXQSQVUJRNS-YYWARMNLSA-N
SMILES O=C1[C@H](C/C=CCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CC2=CC=CC=C2)[C@H](O)C1
Reference

1.Johnson, M.R.,Schaaf, T.K.,Constantine, J.W., et al. Structure activity studies leading to a tissue-selective hypotensive prostaglandin analog, 13,14-dihydro-16-phenyl-ω-tetranor PGE2. Prostaglandins 20, 515-520 (1980).

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