17α-Estradiol

• CAT Number: R013045
• CAS Number: 57-91-0
• Molecular Formula: C18H24O2
• Molecular Weight: 272.388
• Purity: ≥95%
• Synonyms: (17α)-Estra-1,3,5(10)-triene-3,17-diol; 1,3,5-Estratriene-3,17α-diol; 13β-Methyl-1,3,5(10)-gonatriene-3,17α-diol; 17-Epiestradiol; 17α-Oestradiol; 3,17-Dihydroxyestratriene; 3,17α-Dihydroxyoestra-1,3,5(10)-triene; Alfatradiol; Epiestrol; Estra-1,3,5(
• Target: Anti-infection
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at RT
• IUPAC Name: (8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• InChI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
• InChIKey: VOXZDWNPVJITMN-SFFUCWETSA-N
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

17α-Estradiol (CAS 57-91-0), a minor and weak endogenous steroidal estrogen, is a weak agonist of the nuclear estrogen receptors. It shows preferential affinity for the ERα. 17α-Estradiol exerted neuroprotective effects on SK-N-SH cells.

Reference

1.Zhu, Bao Ting, et al. "Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor α and β subtypes: Insights into the structural determinants favoring a differential subtype binding." Endocrinology 147.9 (2006): 4132-4150.
2.Kuiper, George GJM, et al. "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β." Endocrinology 138.3 (1997): 863-870.
3. Green, Pattie S., Jean Bishop, and James W. Simpkins. "17α-Estradiol exerts neuroprotective effects on SK-N-SH cells." Journal of Neuroscience 17.2 (1997): 511-515.