17-AAG

• CAT Number: I004806
• CAS Number: 75747-14-7
• Molecular Formula: C₃₁H₄₃N₃O₈
• Molecular Weight: 585.69
• Purity: ≥95%
• Synonyms: Tanespimycin;17-AAG; KOS-953; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• Target: Metabolic Enzyme/Protease
• Solubility: DMSO: ≥ 55 mg/mL
• Storage: Store at 4°C
• IC50: 5 nM
• IUPAC Name: [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
• InChI: InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
• InChIKey: AYUNIORJHRXIBJ-TXHRRWQRSA-N
• SMILES: C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\C)C)O)OC

17-AAG (17-allylamino-17-demethoxygeldanamycin)(Cat No.:I004806) is a synthetic derivative of geldanamycin and a potent inhibitor of heat shock protein 90 (Hsp90). Hsp90 is a chaperone protein involved in the folding and stabilization of numerous client proteins, many of which are critical for cell growth and survival. By inhibiting Hsp90, 17-AAG disrupts the proper folding and function of client proteins, leading to degradation and/or inhibition of their activity. This can result in the inhibition of multiple signaling pathways involved in cell proliferation, survival, and angiogenesis. 17-AAG has shown promise as an anticancer agent and is being investigated in clinical trials for various types of cancer.