17-O-(Acetyl-d3)-6-methylprednisolone

• CAT Number: R034877
• CAS Number: NA
• Molecular Formula: C₂₄H₂₉D₃O₆
• Molecular Weight: 419.53
• Purity: ≥95%
• Synonyms: (6S,8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl Acetate-d3
• Storage: Store at -20°C
• IUPAC Name: [(6S,8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] 2,2,2-trideuterioacetate
• InChI: InChI=1S/C24H32O6/c1-13-9-16-17-6-8-24(20(29)12-25,30-14(2)26)23(17,4)11-19(28)21(16)22(3)7-5-15(27)10-18(13)22/h5,7,10,13,16-17,19,21,25,28H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,19-,21+,22-,23-,24-/m0/s1/i2D3
• InChIKey: PPTFKULIEDYVJD-UMQNEATBSA-N
• SMILES: [2H]C([2H])([2H])C(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)C)O)C)C(=O)CO

17-O-(Acetyl-d3)-6-methylprednisolone is a deuterated form of 6-methylprednisolone, a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. The deuterium substitution at the acetyl group enhances the stability of the molecule, making it a valuable tool in pharmacokinetic and metabolic studies. This compound is primarily used in pharmaceutical research to investigate the metabolism, distribution, and excretion of corticosteroids. Its applications extend to organic chemistry for studying isotopic effects and in the development of more effective corticosteroid therapies with improved safety profiles.