For research use only. Not for therapeutic Use.
Prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-<wbr></wbr>phenyl trinor PGF<sub>2α</sub> and 16-<wbr></wbr>phenoxy tetranor PGF<sub>2α</sub> are metabolically stable analogs of PGF<sub>2α</sub> and potent agonists for the FP receptor. 17-<wbr></wbr>phenoxy trinor PGF<sub>2α</sub> ethyl amide is a lipophilic analog of 17-<wbr></wbr>phenoxy trinor PGF<sub>2α</sub> (Item No. <span class=/itemid/>10010839</span>). Ethyl amides of PGs serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.
| Catalog Number | R039900 |
| CAS Number | 1421369-12-1 |
| Synonyms | 17-phenoxy trinor PGF2α ethyl amide |
| Molecular Formula | C25H37NO5 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C25H37NO5/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)15-14-19(27)16-17-31-20-10-6-5-7-11-20/h3,5-8,10-11,14-15,19,21-24,27-29H,2,4,9,12-13,16-18H2,1H3,(H,26,30)/b8-3-,15-14+/t19-,21-,22-,23+,24-/m1/s1 |
| InChIKey | QGDXYIFHBPXXOY-HQUSFCFYSA-N |
| SMILES | O[C@@H]1[C@H](C/C=CCCCC(N([H])CC)=O)[C@@H](/C=C/[C@@H](O)CCOC2=CC=CC=C2)[C@H](O)C1 |
| Reference | 1.Samuelsson, B.,Goldyne, M.,Granström, E., et al. Prostaglandins and thromboxanes. Annual Reviews of Biochemistry 47, 997-1029 (1978). |
