(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid (~90percent R)

• CAT Number: R046189
• CAS Number: 671815-99-9
• Molecular Formula: C14H25NO4
• Molecular Weight: 271.357
• Purity: ≥95%
• Synonyms: trans-4-[(1R)-1-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]cyclohexanecarboxylic Acid; trans-4-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]cyclohexanecarboxylic Acid
• Storage: 3 years -20C powder
• IUPAC Name: 4-[(1R)-1-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]cyclohexane-1-carboxylic acid
• InChI: InChI=1S/C14H25NO4/c1-9(15-13(18)19-14(2,3)4)10-5-7-11(8-6-10)12(16)17/h9-11H,5-8H2,1-4H3,(H,15,18)(H,16,17)/t9-,10?,11?/m1/s1
• InChIKey: KLCGIONZGDCLMV-KPPDAEKUSA-N
• SMILES: CC(C1CCC(CC1)C(=O)O)NC(=O)OC(C)(C)C

(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid (CAS 671815-99-9) was used as the intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters.

Reference

1.Gingras, Karine, et al. "Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl) cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters." Bioorganic & medicinal chemistry letters 14.19 (2004): 4931-4934.