1R,3R-RSL3 (negative control)

• CAT Number: I047684
• CAS Number: 1219810-15-7
• Molecular Formula: C23H21ClN2O5
• Molecular Weight: 440.88
• Purity: ≥95%
• IUPAC Name: methyl (1R,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
• InChI: InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21-/m1/s1
• SMILES: COC(=O)[C@H]1CC2=C([C@H](N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24

1R,3R-RSL3 is a negative control compound of the active diastereomer 1S,3R-RSL3, which is available as Axon 3611.
KEYWORDS: 1R,3R-RSL3 | Supplier | GPX4 negative control | CAS [1219810-15-7] | RAS proteins | Ferroptosis | Inhibitor | Proteins | Oncogenic-RAS-synthetic-lethality | Glutathione peroxidase 4 | PhGPx | Ferroptotic cancer cell death

Reference

WS Yang et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1-2):317-331.