(1S,2R)-Alicapistat

• CAT Number: I043485
• CAS Number: 2221010-57-5
• Molecular Formula: C25H27N3O4
• Molecular Weight: 433.50
• Purity: ≥95%
• Synonyms: (2R)-1-benzyl-N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-phenylbutan-2-yl]-5-oxopyrrolidine-2-carboxamide
• InChI: InChI=1S/C25H27N3O4/c29-22-14-13-21(28(22)16-18-9-5-2-6-10-18)24(31)27-20(15-17-7-3-1-4-8-17)23(30)25(32)26-19-11-12-19/h1-10,19-21H,11-16H2,(H,26,32)(H,27,31)/t20-,21+/m0/s1
• InChIKey: MMLDHJRGTZHNHV-LEWJYISDSA-N
• SMILES: C1CC(=O)N([C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)C(=O)NC3CC3)CC4=CC=CC=C4

(1S,2R)-Alicapistat（Cat No.:I043485）is a selective inhibitor of the enzyme retinol dehydrogenase 12 (RDH12), which plays a key role in the metabolism of vitamin A and retinoid signaling. It has been studied for its potential therapeutic applications in retinal diseases, such as macular degeneration and inherited retinal degenerations, where RDH12 dysfunction is implicated. By modulating retinoid metabolism, (1S,2R)-Alicapistat could help restore proper visual function. Its precise stereochemistry (1S,2R) enhances its potency and specificity, making it a promising candidate in the development of targeted treatments for retinal disorders.