For research use only. Not for therapeutic Use.
(1S,2S)-ML-SI3(CAT: I040953) is the trans-isomer of ML-SI3 and acts as a selective inhibitor of TRPML channels. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2, with IC50 values of 1.6 μM and 2.3 μM, respectively, while it weakly inhibits TRPML3 (IC50 = 12.5 μM). In contrast, the (+)-enantiomer selectively inhibits TRPML1 (IC50 = 5.9 μM) but acts as an activator for TRPML2 and TRPML3, with EC50 values of 2.7 μM and 10.8 μM, respectively. This compound is valuable for research in Inflammation & Immunology, particularly in the study of lysosomal storage disorders and autophagy-related pathways.
| CAS Number | 2563870-87-9 |
| Synonyms | N-[(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide |
| Molecular Formula | C23H31N3O3S |
| Purity | ≥95% |
| IUPAC Name | N-[(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide |
| InChI | InChI=1S/C23H31N3O3S/c1-29-23-14-8-7-13-22(23)26-17-15-25(16-18-26)21-12-6-5-11-20(21)24-30(27,28)19-9-3-2-4-10-19/h2-4,7-10,13-14,20-21,24H,5-6,11-12,15-18H2,1H3/t20-,21-/m0/s1 |
| InChIKey | OVTXOMMQHRIKGL-SFTDATJTSA-N |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)[C@H]3CCCC[C@@H]3NS(=O)(=O)C4=CC=CC=C4 |
