1Z105

• CAT Number: I020773
• CAS Number: 1438280-73-9
• Molecular Formula: C25H26N4O2S
• Molecular Weight: 446.57
• Purity: 98%
• Synonyms: 1Z105, 1Z-105, 1Z 105
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-Cyclohexyl-2-((5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide
• InChI: InChI=1S/C25H26N4O2S/c1-28-20-15-9-8-14-19(20)22-23(28)24(31)29(18-12-6-3-7-13-18)25(27-22)32-16-21(30)26-17-10-4-2-5-11-17/h3,6-9,12-15,17H,2,4-5,10-11,16H2,1H3,(H,26,30)
• InChIKey: XIGDXFCDNWREER-UHFFFAOYSA-N
• SMILES: O=C(NC1CCCCC1)CSC2=NC3=C(C(N2C4=CC=CC=C4)=O)N(C)C5=C3C=CC=C5

1Z105(CAT: I020773) is a potent Toll-like receptor 4 (TLR4)/MD2 ligand widely used in immunology and inflammation research. By modulating TLR4 signaling, it significantly reduces interleukin-6 (IL-6) secretion in response to subsequent lipopolysaccharide (LPS) challenge, demonstrating its immunoregulatory properties. 1Z105 is instrumental in studying TLR4-mediated pathways, exploring therapeutic strategies for inflammatory and autoimmune diseases, and understanding immune system modulation. With high specificity and reliability, it is suitable for both in vitro and in vivo applications, providing a robust tool for advancing research into TLR4-related mechanisms and developing targeted therapies for inflammation and immune dysregulation.