2′-Bromo-2′-deoxyuridine

• CAT Number: I041251
• CAS Number: 4753-02-0
• Molecular Formula: C9H11BrN2O5
• Molecular Weight: 307.10
• Purity: ≥95%
• Synonyms: 1-[(2R,3S,5R)-3-bromo-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• IUPAC Name: 1-[(2R,3R,4R,5R)-3-bromo-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• InChI: InChI=1S/C9H11BrN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
• InChIKey: FEUDNSHXOOLCEY-XVFCMESISA-N
• SMILES: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)Br

2′-Bromo-2′-deoxyuridine（Cat No.:I041251）is a nucleoside analogue where the hydrogen atom at the 2′ position of the deoxyribose sugar is replaced with a bromine atom. This modification allows it to incorporate into DNA during replication, where it can disrupt normal DNA synthesis. It is often used as a research tool in molecular biology to study DNA replication, repair mechanisms, and mutagenesis. 2′-Bromo-2′-deoxyuridine has potential applications in cancer research, as it can induce DNA damage in rapidly dividing cells, leading to cell cycle arrest and apoptosis in malignant cells.