2′-Bromo-2′-deoxyuridine

• CAT Number: I041251
• CAS Number: 4753-02-0
• Molecular Formula: C9H11BrN2O5
• Molecular Weight: 307.10
• Purity: ≥95%
• Synonyms: 1-[(2R,3S,5R)-3-bromo-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• InChI: InChI=1S/C9H11BrN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6+,7?,8-/m1/s1
• InChIKey: FEUDNSHXOOLCEY-JDNPWWSISA-N
• SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)Br

2′-Bromo-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Reference

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
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