2-[2-(2-Azidoethoxy)ethoxy]ethanamine

• CAT Number: M135413
• CAS Number: 166388-57-4
• Molecular Formula: C6H14N4O2
• Molecular Weight: 174.2
• Purity: ≥95%
• Target: Antibody-drug Conjugate/ADC Related
• Storage: Store at RT
• IUPAC Name: 2-[2-(2-azidoethoxy)ethoxy]ethanamine
• InChI: InChI=1S/C6H14N4O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-7H2
• InChIKey: ZHWGWSYNZIZTFL-UHFFFAOYSA-N
• SMILES: C(COCCOCCN=[N+]=[N-])N

Azido-PEG2-C2-amine (Cat No.:M135413) is a linker molecule belonging to the polyethylene glycol (PEG) class, commonly used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It enables the connection of a target protein binder with an E3 ubiquitin ligase binder to facilitate targeted protein degradation. Additionally, Azido-PEG2-C2-amine can serve as a non-cleavable linker in the construction of Antibody-Drug Conjugates (ADCs), linking therapeutic payloads to antibodies for targeted delivery in cancer treatment. The inclusion of two PEG units enhances solubility and reduces immunogenicity.