2-[2-(4-Chlorophenyl)ethoxy]adenosine

• CAT Number: R047664
• CAS Number: 131865-88-8
• Molecular Formula: C18H20ClN5O5
• Molecular Weight: 421.838
• Purity: ≥95%
• Synonyms: Sonedenoson; MRE 0094
• Target: adenosine A2A receptor agonist
• Storage: -20°C
• IUPAC Name: (2R,3R,4S,5R)-2-[6-amino-2-[2-(4-chlorophenyl)ethoxy]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
• InChI: InChI=1S/C18H20ClN5O5/c19-10-3-1-9(2-4-10)5-6-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-4,8,11,13-14,17,25-27H,5-7H2,(H2,20,22,23)/t11-,13-,14-,17-/m1/s1
• InChIKey: WUCQGGOGHZRELS-LSCFUAHRSA-N
• SMILES: C1=CC(=CC=C1CCOC2=NC3=C(C(=N2)N)N=CN3C4C(C(C(O4)CO)O)O)Cl

Sonedenoson, also known as MRE0094, is an adenosine A2A receptor agonist, which can effectively promote rapid wound healing. By stimulating adenosine A2A receptor, Sonedenoson increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.

Reference

1:Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Desai A, Victor-Vega C, Gadangi S, Montesinos MC, Chu CC, Cronstein BN.Mol Pharmacol. 2005 May;67(5):1406-13. Epub 2005 Jan 26. PMID: 15673602 Free Article2:Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells. Nguyen DK, Montesinos MC, Williams AJ, Kelly M, Cronstein BN.J Immunol. 2003 Oct 15;171(8):3991-8. PMID: 14530318 Free Article3:Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors. Daly JW, Padgett WL, Secunda SI, Thompson RD, Olsson RA.Pharmacology. 1993;46(2):91-100. PMID: 8441759