2' 3'-DIDEOXYADENOSINE 5'-TRIPHOSPHATE S

• CAT Number: M045583
• CAS Number: 178451-61-1
• Molecular Formula: C10H12N5Na4O11P3
• Molecular Weight: 563.109543
• Purity: ≥95%
• Storage: Desiccate at -20C

2' 3'-DIDEOXYADENOSINE 5'-TRIPHOSPHATE S(CAS 178451-61-1;ddATP)  is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively).It also blocks, in vitro, mammalian and bacterial DNA polymerases. ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2’,3’-dideoxyadenosine, competes with dATP, resulting in chain termination.Because of this activity, dideoxynucleoside 5’-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions. It is also an antagonist of the purinergic receptor P2X2/3 (pIC50 = 6.5).

Reference

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5.Toji, Lorraine, and Seymour S. Cohen. "The enzymatic termination of polydeoxynucleotides by 2′, 3′-dideoxyadenosine triphosphate." Proceedings of the National Academy of Sciences 63.3 (1969): 871-877.
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