CAY10595

• CAT Number: R041625
• CAS Number: 916047-16-0
• Molecular Formula: C20H13Cl2FN2O5
• Molecular Weight: 451.23
• Purity: ≥95%
• Synonyms: 5-chloro-1′-[5-chloro-2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3’pyrrolidine]-1(2H)-acetic acid
• Target: Prostaglandin Receptor
• Storage: -20°C
• IUPAC Name: 2-[5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]acetic acid
• InChI: InChI=1S/C20H13Cl2FN2O5/c21-11-1-3-14(23)10(5-11)8-25-16(26)7-20(19(25)30)13-6-12(22)2-4-15(13)24(18(20)29)9-17(27)28/h1-6H,7-9H2,(H,27,28)
• InChIKey: IXKFWNVFUXXEFY-UHFFFAOYSA-N
• SMILES: C1C(=O)N(C(=O)C12C3=C(C=CC(=C3)Cl)N(C2=O)CC(=O)O)CC4=C(C=CC(=C4)Cl)F

CAY10595(CAT: R041625) is a potent antagonist of the CRTH2/DP2 receptor, which mediates the chemotactic activity of prostaglandin D2 (PGD2) on Th2 cells, eosinophils, and basophils. As a racemic mixture, it binds to the human receptor with a Ki value of 10 nM, while the R-enantiomer is significantly more potent with Ki values of 5.3 nM for humans and 5 nM for murine receptors. The R-enantiomer inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 of 7.3 nM. CAY10595 is crucial in research exploring treatments for allergic and inflammatory diseases, including asthma and allergic rhinitis, through CRTH2/DP2 receptor modulation.