Home
>
Reference Standards>Calcium Channel>
>
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
For research use only. Not for therapeutic Use.
NS-638 is a Ca(2+)-channel blocker. NS-638 dose dependently inhibited K(+)-stimulated [45Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 microM, respectively. K(+)-stimulated intracellular Ca(2+)-elevation in cultured cerebellar granule cells was equipotently blocked with an IC50 value of 3.4 microM.
| Catalog Number | M103997 |
| CAS Number | 150493-34-8 |
| Molecular Formula | C10H16N2O3S |
| Purity | ≥95% |
| Storage | Desiccate at +4C |
| InChI | InChI=1S/C15H11ClF3N3/c16-11-4-1-9(2-5-11)8-22-13-6-3-10(15(17,18)19)7-12(13)21-14(22)20/h1-7H,8H2,(H2,20,21) |
| InChIKey | GXQCVUZORDAARJ-UHFFFAOYSA-N |
| SMILES | FC(C1=CC=C2C(N=C(N)N2CC3=CC=C(Cl)C=C3)=C1)(F)F |
| Reference | </br>1: Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen</br> EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel</br> blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PubMed PMID: 8584126.</br>2: Olesen SP, Møller A, Mordvintcev PI, Busse R, Mülsch A. Regional measurements </br> of NO formed in vivo during brain ischemia. Acta Neurol Scand. 1997</br> Apr;95(4):219-24. PubMed PMID: 9150812.</br></br> |
