2-Amino-5-chlorobenzoxazole (Zoxazolamine)

• CAT Number: R012483
• CAS Number: 61-80-3
• Molecular Formula: C7H5ClN2O
• Molecular Weight: 168.58
• Purity: ≥95%
• Synonyms: 5-Chloro-2-benzoxazolamine; 5-Chloro-1,3-?benzoxazol-2-amine; 5-Chloro-2-aminobenzoxazole; 5-Chlorobenzoxazol-2-ylamine; Deflexol; Flexilon; Flexin; McN-485; NSC 24995; Zoxamin; Zoxine
• Target: Cytochrome P450
• Storage: -20°C
• IUPAC Name: 5-chloro-1,3-benzoxazol-2-amine
• InChI: InChI=1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10)
• InChIKey: YGCODSQDUUUKIV-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1Cl)N=C(O2)N

Zoxazolamine is a potent skeletal muscle relaxant that also has uricosuric activity. It is metabolized by an array of cytochrome P450 (CYP450) isoforms. As a result, recovery time from zoxazolamine-<wbr></wbr>induced paralysis is used as a measure for change in CYP450 expression in mice. Zoxazolamine also dose-<wbr></wbr>dependently modulates the expression of pigmentation factors in a keratinocyte-<wbr></wbr>melanocyte co-culture system.