2-Aminobenzenesulfonamide

• CAT Number: I013037
• CAS Number: 3306-62-5
• Molecular Formula: C₆H₈N₂O₂S
• Molecular Weight: 172.2
• Purity: ≥95%
• Target: Carbonic Anhydrase
• Solubility: DMSO: 160 mg/mL
• Storage: Room temperature
• IUPAC Name: 2-aminobenzenesulfonamide
• InChI: InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
• InChIKey: YAZSBRQTAHVVGE-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)N)S(=O)(=O)N

2-Aminobenzenesulfonamide（Cat No.:I013037） is a compound that acts as a carbonic anhydrase IX (CA-IX) inhibitor. Carbonic anhydrase IX is an enzyme overexpressed in certain types of tumors, particularly in hypoxic conditions. By inhibiting CA-IX, 2-Aminobenzenesulfonamide interferes with the enzyme’s function in regulating pH and bicarbonate levels, which can contribute to tumor growth and metastasis. The inhibition of CA-IX by 2-Aminobenzenesulfonamide represents a potential therapeutic strategy for targeting CA-IX-expressing tumors and impeding their progression.

Reference

[1]. Vullo D, et al. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1005-9.