2-((Azido-PEG8-carbamoyl)methoxy)acetic acid

• CAT Number: I015983
• CAS Number: 846549-37-9
• Molecular Formula: C₂₂H₄₂N₄O₁₂
• Molecular Weight: 554.59
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid
• InChI: InChI=1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29)
• InChIKey: WWDNBBVPYDZICO-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])NC(=O)COCC(=O)O

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid (Cat.No: I015983) is a derivative of polyethylene glycol (PEG) that is commonly used in bioconjugation and drug delivery. The azide group on the PEG chain allows for easy attachment to biomolecules through copper-catalyzed azide-alkyne cycloaddition (Click chemistry).

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562