2-BP (2-Bromohexadecanoic acid)

• CAT Number: M079814
• CAS Number: 18263-25-7
• Molecular Formula: C16H31BrO2
• Molecular Weight: 335.32
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CCCCCCCCCCCCCCC(Br)C(O)=O

2-BP (2-Bromohexadecanoic acid) is a nonmetabolisable analogue of palmitate and acts as a palmitoylation inhibitor, which inhibits multiple palmitoyl-acyl transferase (PAT) activity towards MyrGCK(NBD) and FarnCNRas(NBD) with identical IC50s of approx. 4 µM. 2-Bromohexadecanoic acid can directly and irreversibly inhibit the palmitoyltransferase activity of all DHHC (Asp-His-His-Cys) proteins.

Reference

[1] Lei Hu, et al. Cell Death Dis. 2020 Apr 24;11(4):281.
[2] Varner AS, et al. Biochem J. 2003 Jul 1;373(Pt 1):91-9.