2-Demethyl Colchicine

• CAT Number: R001520
• CAS Number: 102491-80-5
• Molecular Formula: C21H23NO6
• Molecular Weight: 385.42
• Purity: ≥95%
• Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; O2-Demethylcolchicine; (-)-2-Demethylcolchicine;NSC 180533
• Storage: -20°C
• IUPAC Name: N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• InChI: InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-18(27-3)20(25)21(28-4)19(12)13-6-8-17(26-2)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1
• InChIKey: DPOVAJCRYIUTBD-HNNXBMFYSA-N
• SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)O)OC

2-Demethyl colchicine（Cat No.:R001520） is a derivative of colchicine, a natural compound derived from the autumn crocus (Colchicum autumnale) plant. This derivative lacks one methyl group compared to colchicine. It exhibits similar biological activities to colchicine, including anti-inflammatory, anti-gout, and anticancer properties. 2-Demethyl colchicine has shown promise in preclinical studies for its ability to inhibit tubulin polymerization, a mechanism critical for cell division, making it a potential cancer treatment. Its reduced toxicity compared to colchicine makes it an attractive candidate for further drug development. However, more research is needed to fully understand its therapeutic potential and safety profile.