2’-Deoxy-N1-methylguanosine

• CAT Number: I041274
• CAS Number: 5132-79-6
• Molecular Formula: C11H15N5O4
• Molecular Weight: 281.27
• Purity: ≥95%
• Synonyms: 2-amino-9-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methylpurin-6-one
• InChI: InChI=1S/C11H15N5O4/c1-15-10(19)8-9(14-11(15)12)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14)/t5?,6-,7-/m1/s1
• InChIKey: VJSHSPNFYFRXGN-JXBXZBNISA-N
• SMILES: CN1C(=O)C2=C(N=C1N)N(C=N2)C3CC(C(O3)CO)O

2’-Deoxy-N1-methylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Reference

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
 [Content Brief]