For research use only. Not for therapeutic Use.
MRS2179 is a competitive P2Y1 receptor antagonist (Kb = 100 nM) with no appreciable activity at P2Y2, P2Y4, or P2Y6 at concentrations up to 30 µM, or at P2Y12 and P2Y13. It inhibits ADP-induced platelet shape change and aggregation (pA2 = 6.55) in vitro and prolongs bleeding time in rats and mice compared to controls.
| Catalog Number | M012067 |
| CAS Number | 101204-49-3 |
| Synonyms | 2′-deoxy-N-methyl-5′-(dihydrogen phosphate), 3′-adenylic acid |
| Molecular Formula | C11H17N5O9P2 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/p-2 |
| InChIKey | CCPLITQNIFLYQB-XLPZGREQSA-N |
| SMILES | CNC1=NC=NC2=C1N=CN2[C@H]3C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O3 |
| Reference | </br>1: Zhuo T, Zhou S, Zhang W, Lambertucci C, Volpini R. Synthesis and Ability of</br> New Ligands for G Protein-Coupled Receptors 17 (GPR17). Med Sci Monit. 2017 Feb</br> 22;23:953-959. PubMed PMID: 28223679; PubMed Central PMCID: PMC5333714.</br>2: Certal M, Vinhas A, Barros-Barbosa A, Ferreirinha F, Costa MA, Correia-de-Sá</br> P. ADP-Induced Ca(2+) Signaling and Proliferation of Rat Ventricular</br> Myofibroblasts Depend on Phospholipase C-Linked TRP Channels Activation Within</br> Lipid Rafts. J Cell Physiol. 2017 Jun;232(6):1511-1526. doi: 10.1002/jcp.25656.</br> Epub 2016 Nov 10. PubMed PMID: 27755650.</br>3: de Almeida-Pereira L, Magalhães CF, Repossi MG, Thorstenberg ML, Sholl-Franco </br> A, Coutinho-Silva R, Ventura AL, Fragel-Madeira L. Adenine Nucleotides Control</br> Proliferation In Vivo of Rat Retinal Progenitors by P2Y(1) Receptor. Mol</br> Neurobiol. 2016 Aug 24. [Epub ahead of print] PubMed PMID: 27558237.</br></br> |
