2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite

• CAT Number: I041273
• CAS Number: 329187-86-2
• Molecular Formula: C47H51FN7O7P
• Molecular Weight: 875.92
• Purity: ≥95%
• Synonyms: N-[9-[(2R,3R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]benzamide
• IUPAC Name: N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]benzamide
• InChI: InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-39(61-46(40(42)48)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)
• InChIKey: VCCMVPDSLHFCBB-UHFFFAOYSA-N
• SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

2′-Fluoro-2′-deoxy-ara-A(Bz)-3′-phosphoramidite（Cat No.:I041273）is a modified nucleoside analogue used in DNA and RNA synthesis. It features a 2′-fluoro substitution on the deoxyribose sugar, enhancing its resistance to exonuclease degradation, and a benzoyl (Bz) group protecting the nucleoside’s 5′ position during synthesis. The phosphoramidite group allows for efficient incorporation into oligonucleotides via solid-phase synthesis. This compound is valuable in research focused on designing stable oligonucleotides for gene editing, antisense therapies, and antiviral applications. Its modifications make it a useful tool for studying nucleic acid interactions and improving the stability of therapeutic oligonucleotides.