2-Hydroxy-4-methylbenzenesulphonic acid ammonium

• CAT Number: R033413
• CAS Number: 79093-71-3
• Molecular Formula: C7H11NO4S
• Molecular Weight: 205.23
• Purity: ≥95%
• Synonyms: azane;2-hydroxy-4-methylbenzenesulfonic acid
• InChI: InChI=1S/C7H8O4S.H3N/c1-5-2-3-7(6(8)4-5)12(9,10)11;/h2-4,8H,1H3,(H,9,10,11);1H3
• InChIKey: KGBVTRPJPQHXSU-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)S(=O)(=O)O)O.N

2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability[1].

Reference

[1]. Deng-wei Wu, et al. Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells. Acta Pharmacol Sin. 2015 Sep;36(9):1126-36.
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