2-Hydroxychalcone

• CAT Number: M185554
• CAS Number: 644-78-0
• Molecular Formula: C15H12O2
• Molecular Weight: 224.25
• Purity: ≥95%
• Target: NF-κB
• IUPAC Name: (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
• InChI: InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)10-11-15(17)12-6-2-1-3-7-12/h1-11,16H/b11-10+
• InChIKey: UDOOPSJCRMKSGL-ZHACJKMWSA-N
• SMILES: C1=CC=C(C=C1)C(=O)C=CC2=CC=CC=C2O

2-Hydroxychalcone（Cat No.:M185554）, a natural flavonoid, exhibits antioxidant properties and inhibits lipid peroxidation. It also demonstrates apoptotic effects by downregulating Bcl-2, a protein involved in inhibiting apoptosis. Additionally, 2-hydroxychalcone can inhibit the activation of NF-kB, a transcription factor involved in inflammation and immune responses. Through these mechanisms, 2-hydroxy chalcone may have potential therapeutic applications in conditions related to oxidative stress, apoptosis dysregulation, and NF-kB-mediated inflammation.