For research use only. Not for therapeutic Use.
2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2)[1][2].
2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement[3].
| Catalog Number | I012900 |
| CAS Number | 109544-45-8 |
| Synonyms | 2-(3-methoxy-2H-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole;hydrochloride |
| Molecular Formula | C12H15ClN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H |
| InChIKey | IMPOOMVZVWKSAP-UHFFFAOYSA-N |
| SMILES | COC1(COC2=CC=CC=C2O1)C3=NCCN3.Cl |
| Reference | [1]. Head GA. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. Ann N Y Acad Sci. 1995;763:531-540. [2]. Trendelenburg AU, et al. Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1996;353(3):245-249. [3]. Sandner G, et al. Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion. Front Behav Neurosci. 2014;8:15. Published 2014 Jan 28. |
