2-O-DMT-Sulfonyldiethanol phosphoramidite

• CAT Number: M003324
• CAS Number: 108783-02-4
• Molecular Formula: C34H45N2O7PS
• Molecular Weight: 656.77
• Purity: ≥95%
• Synonyms: 3-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethylsulfonyl]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• InChI: InChI=1S/C34H45N2O7PS/c1-27(2)36(28(3)4)44(42-22-10-21-35)43-24-26-45(37,38)25-23-41-34(29-11-8-7-9-12-29,30-13-17-32(39-5)18-14-30)31-15-19-33(40-6)20-16-31/h7-9,11-20,27-28H,10,22-26H2,1-6H3
• InChIKey: RJDYWMSSNMDIOO-UHFFFAOYSA-N
• SMILES: CC(C)N(C(C)C)P(OCCC#N)OCCS(=O)(=O)CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

​2-O-DMT-Sulfonyldiethanol phosphoramidite(CAT: M003324) is a phosphoramidite reagent used in the solid-phase synthesis of oligonucleotides to introduce sulfonyl groups into DNA or RNA molecules. Its structure includes a 2-O-DMT (4,4′-dimethoxytrityl) protecting group and a sulfonyldiethanol moiety, facilitating the incorporation of sulfonyl functionalities during nucleic acid synthesis. This modification is valuable for various biochemical applications, including studies on nucleic acid interactions and the development of therapeutics. The compound has a molecular formula of C₃₄H₄₅N₂O₇PS and a molecular weight of 656.77 g/mol. It is typically stored at 2-8°C under nitrogen to maintain stability.