2'-O-MOE-U

• CAT Number: M046049
• CAS Number: 163759-97-5
• Molecular Formula: C42H53N4O10P
• Molecular Weight: 804.86
• Purity: ≥95%
• Synonyms: 3-[[(2R,4S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(2-methoxyethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(2-methoxyethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• InChI: InChI=1S/C42H53N4O10P/c1-29(2)46(30(3)4)57(54-25-11-23-43)56-38-36(55-40(39(38)52-27-26-49-5)45-24-22-37(47)44-41(45)48)28-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,48)/t36-,38-,39-,40-,57?/m1/s1
• InChIKey: ZLOKLUONKGURQI-UAQIPLLRSA-N
• SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

2′-O-MOE-U (Cat No.:M046049) is a modified nucleoside analog in which the 2′-hydroxyl group of uridine is replaced with a methoxyethyl group. This modification increases the stability of the nucleoside by making it more resistant to enzymatic degradation, particularly by ribonucleases. The enhanced stability makes 2′-O-MOE-U a useful tool in RNA-based therapeutics, such as in antisense oligonucleotides or RNA interference therapies, as it improves the pharmacokinetics and bioavailability of RNA molecules. Its potential applications include treating genetic disorders, viral infections, and cancer through targeted RNA modulation.