2'-O-Propargyl g(iBu)-3'-phosphoramidite

• CAT Number: L022146
• CAS Number: 171486-61-6
• Molecular Formula: C47H56N7O9P
• Molecular Weight: 894.94
• Purity: ≥95%
• Target: Nucleoside Antimetabolite/Analog
• IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
• InChI: InChI=1S/C47H56N7O9P/c1-10-26-59-41-40(63-64(61-27-14-25-48)54(31(4)5)32(6)7)38(62-45(41)53-29-49-39-42(53)50-46(52-44(39)56)51-43(55)30(2)3)28-60-47(33-15-12-11-13-16-33,34-17-21-36(57-8)22-18-34)35-19-23-37(58-9)24-20-35/h1,11-13,15-24,29-32,38,40-41,45H,14,26-28H2,2-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1
• InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
• SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCC#C

2′-O-Propargyl g(iBu)-3′-phosphoramidite(CAT: L022146) is a specialized nucleotide derivative used extensively in oligonucleotide synthesis. This compound features a propargyl group on the 2′-hydroxyl and an isobutyryl-protected guanine base, along with a 3′-phosphoramidite functional group for efficient incorporation into RNA or DNA sequences. It is particularly valuable in the preparation of modified oligonucleotides, enabling applications such as click chemistry for conjugation, fluorescent labeling, and the study of nucleic acid structure and function. 2′-O-Propargyl g(iBu)-3′-phosphoramidite is essential for advanced research in molecular biology, therapeutics, and diagnostic development.