For research use only. Not for therapeutic Use.
2′-O,4′-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2′-O,4′-C-Methylenecytidine can be used to synthesize oligonucleotides. 2′-O,4′-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands[1][2].
| Catalog Number | I042978 |
| CAS Number | 206055-69-8 |
| Synonyms | 4-amino-1-[(1S,3R,4S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidin-2-one |
| Molecular Formula | C10H13N3O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H13N3O5/c11-5-1-2-13(9(16)12-5)8-6-7(15)10(3-14,18-8)4-17-6/h1-2,6-8,14-15H,3-4H2,(H2,11,12,16)/t6-,7?,8+,10-/m0/s1 |
| InChIKey | FCMRQQIZHFHCNG-MZGKANMLSA-N |
| SMILES | C1C2(C(C(O1)C(O2)N3C=CC(=NC3=O)N)O)CO |
| Reference | [1]. bicyclic nucleoside analogue, N-type conformation, synthesize oligonucleotides, duplexes [2]. Obika S, et, al. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides. Tetrahedron Letters. 1998 Jul 23; 39(30):5401-04. |
