For research use only. Not for therapeutic Use.
2′-O,4′-C-Methyleneguanosine（Cat No.:I042980）is a modified guanosine analog where the 2′-oxygen and the 4′-carbon of the ribose ring are replaced by a methylene group. This structural alteration enhances the compound’s stability by protecting it from enzymatic degradation, particularly from ribonucleases. The modification also improves its resistance to hydrolysis, making it more suitable for therapeutic applications. 2′-O,4′-C-Methyleneguanosine can be used in RNA-related research and has potential in antiviral, anticancer, and gene therapy applications by stabilizing RNA molecules and modulating their activity in a targeted manner.
| CAS Number | 207131-16-6 |
| Synonyms | 2-amino-9-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-1H-purin-6-one |
| Molecular Formula | C11H13N5O5 |
| Purity | ≥95% |
| IUPAC Name | 2-amino-9-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-1H-purin-6-one |
| InChI | InChI=1S/C11H13N5O5/c12-10-14-7-4(8(19)15-10)13-3-16(7)9-5-6(18)11(1-17,21-9)2-20-5/h3,5-6,9,17-18H,1-2H2,(H3,12,14,15,19)/t5-,6+,9-,11+/m1/s1 |
| InChIKey | OZVMOEUWPMYRQU-JUQFDLSGSA-N |
| SMILES | C1[C@]2([C@H]([C@@H](O1)[C@@H](O2)N3C=NC4=C3N=C(NC4=O)N)O)CO |
