2-Oxo Clopidogrel (Mixture of Isomers)

• CAT Number: R045327
• CAS Number: 109904-27-0
• Molecular Formula: C16H17Cl2NO3S
• Molecular Weight: 374.276
• Purity: ≥95%
• Synonyms: α-(2-Chlorophenyl)-2,6,7,7a-tetrahydro-2-oxo-thieno[3,2-c]pyridine-5(4H)-acetic Acid Methyl Ester
• Storage: -20°C
• IUPAC Name: methyl 2-(2-chlorophenyl)-2-(2-oxo-4,6,7,7a-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate;hydrochloride
• InChI: InChI=1S/C16H16ClNO3S.ClH/c1-21-16(20)15(11-4-2-3-5-12(11)17)18-7-6-13-10(9-18)8-14(19)22-13;/h2-5,8,13,15H,6-7,9H2,1H3;1H
• InChIKey: KCFLQPXPVKZERK-UHFFFAOYSA-N
• SMILES: COC(=O)C(C1=CC=CC=C1Cl)N2CCC3C(=CC(=O)S3)C2.Cl

2-oxo Clopidogrel is an intermediary metabolite of clopidogrel (Item No. 13657). Clopidogrel is a prodrug that is converted to its active metabolite via two sequential oxidative steps. The first step leads to formation of 2-oxo clopidogrel, followed by conversion to the active metabolite, which binds specifically and irreversibly to the platelet P2Y12 purinergic receptor, inhibiting ADP-mediated platelet activation and aggregation.