For research use only. Not for therapeutic Use.
(2-Pyridyldithio)-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016474 |
| CAS Number | 2144777-73-9 |
| Synonyms | tert-butyl 3-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]propanoate |
| Molecular Formula | C16H25NO4S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H25NO4S2/c1-16(2,3)21-15(18)7-9-19-10-11-20-12-13-22-23-14-6-4-5-8-17-14/h4-6,8H,7,9-13H2,1-3H3 |
| InChIKey | NFTUEHOZCVWJPT-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCSSC1=CC=CC=N1 |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
