(2-pyridyldithio)-PEG4 acid

• CAT Number: I016172
• CAS Number: 581065-93-2
• Molecular Formula: C16H25NO6S2
• Molecular Weight: 391.50
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C16H25NO6S2/c18-16(19)4-6-20-7-8-21-9-10-22-11-12-23-13-14-24-25-15-3-1-2-5-17-15/h1-3,5H,4,6-14H2,(H,18,19)
• InChIKey: YOJQJVOLXIGESQ-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)SSCCOCCOCCOCCOCCC(=O)O

(2-pyridyldithio)-PEG4 acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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