For research use only. Not for therapeutic Use.
(2-Pyridyldithio)-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016476 |
| CAS Number | 851961-99-4 |
| Synonyms | 2-[2-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]ethoxy]ethanol |
| Molecular Formula | C13H21NO4S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H21NO4S2/c15-5-6-16-7-8-17-9-10-18-11-12-19-20-13-3-1-2-4-14-13/h1-4,15H,5-12H2 |
| InChIKey | NVGYTXVKRZYCDH-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)SSCCOCCOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
