2-Thenoyltrifluoroacetone

• CAT Number: R029595
• CAS Number: 326-91-0
• Molecular Formula: C8H5F3O2S
• Molecular Weight: 222.181
• Purity: ≥95%
• Synonyms: 1,1,1-Trifluoro-3-(2-thenoyl)acetone; 1,1,1-Trifluoro-4-(2-thienyl)-2,4-butanedione;1-(2-Thienyl)-4,4,4-trifluoro-1,3-butanedione; 1-(2-Thienyl)-4,4,4-trifluorobutane-1,3-dione; 1-Thenoyl-3,3,3-trifluoroacetone?2-(4,4,4-Trifluoroacetoacetyl)thiophene
• Storage: -20°C
• IUPAC Name: 4,4,4-trifluoro-1-thiophen-2-ylbutane-1,3-dione
• InChI: InChI=1S/C8H5F3O2S/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
• InChIKey: TXBBUSUXYMIVOS-UHFFFAOYSA-N
• SMILES: C1=CSC(=C1)C(=O)CC(=O)C(F)(F)F

2-Thenoyltrifluoroacetone (TTFA) is an inhibitor of respiration in animals and bacteria. In animals, TTFA binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II), preventing ubiquinone from binding. It inhibits NADH fumarate reductase in bacteria. TTFA also inhibits photosystem II in plants and NADH-ubiquinone oxidoreductase of the virus Vibrio cholerae, decreasing cholera toxin production. This compound is also a chelator of metals, including lanthanum, zirconium, hafnium, and neodymium.