20-HETE

• CAT Number: I004903
• CAS Number: 79551-86-3
• Molecular Formula: C20H32O3
• Molecular Weight: 320.47
• Purity: ≥95%
• Synonyms: (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid
• Target: ATPase
• Solubility: DMSO: ≥ 3.2 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
• InChIKey: NNDIXBJHNLFJJP-DTLRTWKJSA-N
• SMILES: C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO

20-HETE (Cat.No: I004903), or 20-hydroxyeicosatetraenoic acid, is a metabolite of arachidonic acid that has been implicated in various physiological processes, including regulation of blood pressure, renal function, and inflammation. It acts as a vasoconstrictor and can also affect ion channels and cellular signaling pathways. Dysregulation of 20-HETE has been associated with various diseases, such as hypertension, stroke, and cancer.

Reference

[1]. Zou AP, Fleming JT, Falck JR, 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol. 1996 Jan;270(1 Pt 2):R228-37.

[2]. Schwartzman M, Ferreri NR, Carroll MA, Renal cytochrome P450-related arachidonate metabolite inhibits (Na+ + K+)ATPase. Nature. 1985 Apr 18-24;314(6012):620-2.

[3]. Ding Y, Wu CC, Garcia V, 20-HETE INDUCES REMODELING OF RENAL RESISTANCE ARTERIES INDEPENDENT OF BLOOD PRESSURE ELEVATION IN HYPERTENSION. Am J Physiol Renal Physiol. 2013 Jul 3. [Epub ahead of print]

[4]. Lai G, Wu J, Liu X, 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway. Mol Endocrinol. 2012 Nov;26(11):1907-16.