CONTACT US
Home > Inhibitors/Agonists> > (20R)-Ginsenoside Rg3
38243-03-7-(20R)-Ginsenoside Rg3 (20R)-Ginsenoside Rg3

(20R)-Ginsenoside Rg3

For research use only. Not for therapeutic Use.

  • CAT Number: I018568
  • CAS Number: 38243-03-7
  • Molecular Formula: C42H72O13
  • Molecular Weight: 785.01
  • Purity: ≥95%
Inquiry Now
Related Small Molecules: Agathisflavone     Navacaprant     Myelin Basic Protein(87-99) TFA    

(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects[1].
(20R)-ginsenoside Rg3 inhibits the proliferation of human umbilical vein endothelial cells (HUVEC) with an IC50 of 10 nM[1].
(20R)-ginsenoside Rg3 also dose dependently suppresses the capillary tube formation of HUVEC on the Matrigel in the presence or absence of 20 ng/mL VEGF[1].
(20R)-ginsenoside Rg3 significantly attenuates the VEGF-induced chemoinvasion of HUVEC and ex vivo microvascular sprouting in rat aortic ring assay[1].
(20R)-ginsenoside Rg3 (150 and 600 nM) remarkably abolishes the basic fibroblast growth factor (bFGF)-induced angiogenesis in an in vivo Matrigel plug assay[1].
(20R)-ginsenoside Rg3 (0.05-0.5 mg/kg; intranasal administration; for 2 weeks) shows anti-fatigue effect in mice by intranasally administration[2].


Catalog Number I018568
CAS Number 38243-03-7
Synonyms

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Molecular Formula C42H72O13
Purity ≥95%
InChI InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26?,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42+/m0/s1
InChIKey RWXIFXNRCLMQCD-QFISXMCJSA-N
SMILES CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)O)C
Reference

[1]. Yue PY, et al. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45.
 [Content Brief]

[2]. Wenyan Tang, et al. The anti-fatigue effect of 20(R)-ginsenoside Rg3 in mice by intranasally administration. Biol Pharm Bull. 2008 Nov;31(11):2024-7.
 [Content Brief]

Request a Quote